Clemson vs. Florida State prediction, odds, spread, line, time: 2023 college football picks from pro

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No. 4 Florida State will travel to Clemson for an early-season ACC showdown on Saturday afternoon. The Seminoles are riding a nine-game winning streak dating back to last season after squeaking out a 31-29 win at Boston College last week. Clemson was blown out by Duke in its opener, but it has bounced back with a pair of blowout wins. The Tigers have won the ACC title in seven of the past eight seasons, and they have won four straight meetings between these teams in Death Valley.

Kickoff is set for noon ET at Memorial Stadium. The latest Clemson vs. Florida State odds via the SportsLine consensus list the Seminoles as 2-point favorites, with the over/under at 55. Before making any Florida State vs. Clemson picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has gotten off to a hot start in 2023, going 4-1 in his football picks for SportsLine. Anyone who has followed his picks is way up.

Now, he has set his sights on Clemson vs. Florida State and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for FSU vs. Clemson:

  • Clemson vs. Florida State spread: Seminoles -2
  • Clemson vs. Florida State over/under: 55 points
  • Clemson vs. Florida State money line: Florida State -132, Clemson +111
  • CLEM: RB Will Shipley is averaging 6.3 yards per carry
  • FSU: QB Jordan Travis has accounted for 9 TDs in 2023
  • Clemson vs. Florida State picks: See picks at SportsLine
  • Clemson vs. Florida State live stream: fubo (try for free)

Why Clemson can cover

The Tigers have one of the best home field advantages in college football. The crowd at Death Valley will be raucous, and Clemson is the last team to defeat Florida State, beating the Noles 34-28 in Tallahassee in 2022. The last time Florida State defeated Clemson was in 2014 when the Seminoles were the No. 1 ranked team in the country. 

The Tigers have had some issues on the offensive side of the ball, but once again have one of the best defenses in the country. Clemson enters this matchup allowing just 246.7 total yards of offense (148.7 passing, 98 rushing), and their defensive front could give Florida State fits. Linebackers Jeremiah Trotter Jr. and Barrett Carter, and defensive linemen Xavier Thomas and Tyler Davis are all considered to be high-level NFL prospects. See who to back at SportsLine. 

Why Florida State can cover

Florida State has already proven itself on the national stage once this season, cruising to a 45-24 win against then-No. 5 LSU in its season opener. The Seminoles added a blowout win over Southern Miss before hanging on for a win at Boston College last week. They have covered the spread in six of their last seven road games, and they are 13-6 against the spread in their last 19 games overall.

Clemson has won seven straight games against Florida State, but it has only covered the spread twice in its last six games. The Tigers have also covered the spread just twice in their last 14 September games, and they came up way short in their lone meeting with a Power 5 school this season. Florida State leads the all-time series against Clemson by a tally of 20-15, and the Seminoles are in a position to extend that lead on Saturday. See who to back at SportsLine. 

How to make Clemson vs. Florida State picks

Kaylor has analyzed this matchup from every angle and he's leaning Under on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Clemson vs. Florida State on Saturday, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Clemson vs. Florida State picks, all from the expert who has covered college football for over a decade and is 4-1 on his football best bets for SportsLine in 2023, and find out.

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